Endocrine Abstracts

Acromegaly is due to increased GH secretion usually sustained by a GH-secreting pituitary adenoma. Somatostatin analogues (SSA) can control GH hypersecretion in 60% of patients and tumor volume in 30%. The disease control is, in turn, associated with lower mortality and therefore to verify the optimal control of the disease activity is of critical importance to adapt the dose and the choice of alternative treatment. The criteria for optimized disease control had been assumed a...

Introduction: Prediction of HPA (hypothalamus-pituitary-adrenal) activity after trans-sphenoidal pituitary surgery (NS) is essential for post-operative management. There is not unique behavior in this setting: most of specialists suggests 4-6 weeks of glucocorticoid supplementation and treatment interruption after demonstration of normal endogenous response. Some authors suggest early cortisol detection for the identification of patients requiring glucocorticoid therapy. Aim o...

Context: Hyponatremia is associated with an increased risk of osteoporosis and fractures, and in recent years increasing evidence is accumulating in favor of a likely causal relationship between hyponatremia and bone loss. In rat models, the induction of hyponatremia enhances osteoclast activation and bone catabolism. In humans, the correction of hyponatremia by tolvaptan or SGLT2-inhibitors has a favorable effect on bone turnover markers, possibly due to an interplay both wit...